Description
Protontherapy is a recent technology aiming at treating cancer by delivering high radiation doses to the tumour in the form of a proton beam. Whereas the added value of protontherapy over conventional radiotherapy (using photons) has been previously demonstrated in many cancers, the effects on such therapies at the tissue- and cellular level are still not fully documented. One major difficulty in studying these effects is to relate the macroscopic (pre-)clinical information obtained in-vivo to the finer microscopic cellular information obtained ex-vivo. In this context, developing novel techniques for registration (“matching”) between both imaging scales is of utmost importance, which is the subject of the proposed thesis work.
As a PhD candidate, you will conduct original scientific research end-to-end. You will propose novel approaches to address the registration problem between microscopic (ex-vivo) high-resolution images and macroscopic (in-vivo) pre-clinical images in brain and liver cancer. You will use the developed tools to address scientific questions in the field of oncology and (radio-)biology. You will share your work through international scientific congresses and publications. You will take part to the scientific and academic life of the innovative LISA laboratory (Ecole Polytechnique de Bruxelles, ULB) and integrate the large inter-university consortium Prother-Wal. By the end of your fellowship, you will obtain a valuable PhD degree from Ecole Polytechnique de Bruxelles.
Contact
Corentin MARTENS (corentin.martens@ulb.be)
Christine DECAESTECKER (christine.decaestecker@ulb.be)
Gaetan VAN SIMAEYS (gaetan.vansimaeys@ulb.be)